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Inside Cover: Design, Synthesis, and Antibacterial Activity of Demethylvancomycin Analogues against Drug‐Resistant Bacteria (ChemMedChem 6/2013)
Author(s) -
Chang Jun,
Zhang SiJi,
Jiang YongWei,
Xu Liang,
Yu JianMing,
Zhou WenJiang,
Sun Xun
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201390021
Subject(s) - enterococcus faecalis , bacteria , peptidoglycan , chemistry , hydrogen bond , antibacterial activity , combinatorial chemistry , stereochemistry , cover (algebra) , drug discovery , biochemistry , enzyme , escherichia coli , biology , organic chemistry , molecule , genetics , mechanical engineering , engineering , gene
The inside cover picture shows the proposed binding mode of a demethylvancomycin analogue (white) with the peptidoglycan of vancomycin‐resistant Enterococcus faecalis (teal), in which the NH–π interaction is predicted to compensate for the diminished binding affinity caused by the breaking of a conserved NH ⋅ ⋅ ⋅ O hydrogen bond in drug‐resistant bacteria. For more details, see the Full Paper by Wen‐Jiang Zhou, Xun Sun et al. on p. 976 ff.