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Cover Picture: From a Multipotent Stilbene to Soluble Epoxide Hydrolase Inhibitors with Antiproliferative Properties (ChemMedChem 6/2013)
Author(s) -
Buscató Estel.la,
Büttner Dominik,
Brüggerhoff Astrid,
Klingler FrancaMaria,
Weber Julia,
Scholz Bastian,
Živković Aleksandra,
Marschalek Rolf,
Stark Holger,
Steinhilber Dieter,
Bode Helge B.,
Proschak Ewgenij
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201390020
Subject(s) - epoxide hydrolase 2 , front cover , chemistry , natural product , epoxide , cover (algebra) , stereochemistry , combinatorial chemistry , biochemistry , enzyme , catalysis , mechanical engineering , engineering
The front cover picture shows the structure of the multipotent bacterial isopropylstilbene identified as a novel soluble epoxide hydrolase (sEH) inhibitor with antiproliferative properties. This natural product served as a template for the design and synthesis of ( E )‐styryl‐1 H ‐benzo[ d ]imidazoles—easily accessible compounds with enhanced activity towards sEH. The modeled conformation of one of the designed compounds is shown in the foreground, and the background displays apoptotic cells after treatment with isopropylstilbene. For more details, see the Communication by Ewgenij Proschak et al. on p. 919 ff.