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Inside Cover: Artemisinin–Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation (ChemMedChem 5/2013)
Author(s) -
La Pensée Louise,
Sabbani Sunil,
Sharma Raman,
Bhamra Inder,
Shore Emma,
Chadwick Amy E.,
Berry Neil G.,
Firman James,
Araujo Nuna C.,
Cabral Lília,
Cristiano Maria L. S.,
Bateman Cerys,
Janneh Omar,
Gavrila Adelina,
Wu Yi Hang,
Hussain Afthab,
Ward Stephen A.,
Stocks Paul A.,
Cosstick Rick,
O'Neill Paul M.
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201390016
Subject(s) - netropsin , conjugate , artemisinin , linker , chemistry , dna , combinatorial chemistry , stereochemistry , anticancer drug , duplex (building) , minor groove , biochemistry , drug , biology , computer science , pharmacology , mathematical analysis , mathematics , malaria , immunology , plasmodium falciparum , operating system
The inside cover picture shows a DNA‐targeting artemisinin–netropsin drug conjugate docked into d(CGCGAATTCGCG) duplex DNA (PDB code: 1D86). The conjugate combines a trioxane warhead and a minor groove binder joined through a phenyl linker. For more details, see the Communication by Paul M. O'Neill et al. on p. 709 ff.