Premium
Inside Cover: Effect of C7 Modifications on Benzothiadiazine‐1,1‐dioxide Derivatives on Their Inhibitory Activity and Selectivity toward Aldose Reductase (ChemMedChem 4/2013)
Author(s) -
Zhang Shuzhen,
Chen Xin,
Parveen Shagufta,
Hussain Saghir,
Yang Yanchun,
Jing Chaojun,
Zhu Changjin
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201390011
Subject(s) - aldose reductase , benzothiadiazine , chemistry , pharmacophore , selectivity , aldose reductase inhibitor , aldehyde reductase , stereochemistry , combinatorial chemistry , biochemistry , enzyme , medicinal chemistry , catalysis
The inside cover picture shows a benzothiadiazine‐1,1‐dioxide inhibitor of aldose reductase (ALR2) bound in the active site. Structure–activity relationship studies led to inhibitors with enhanced activity and selectivity, highlighting the important role of the C7 side chain and providing insight into the pharmacophore requirements for ALR2 inhibition. For more details, see the Full Paper by Changjin Zhu et al. on p. 603 ff.