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Back Cover: A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents (ChemMedChem 2/2013)
Author(s) -
Chen Haijun,
Wang Cheng Z.,
Ding Chunyong,
Wild Christopher,
Copits Bryan,
Swanson Geoffrey T.,
Johnson Kenneth M.,
Zhou Jia
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201390004
Subject(s) - ampa receptor , allosteric regulation , cheminformatics , bivalent (engine) , chemistry , neuroprotection , computational biology , allosteric modulator , in vivo , pharmacology , receptor , stereochemistry , biochemistry , biology , nmda receptor , genetics , organic chemistry , computational chemistry , metal
The back cover picture shows the rational design of asymmetric bivalent positive allosteric modulators (PAMs) of the α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor by using an effective, combined bio‐ and chemoinformatic approach. These ligands display marked potency in vitro and efficacy in vivo for preventing neuroapoptosis. For more details, see the Communication by Jia Zhou et al. on p. 226 ff.