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Inside Cover: Synthesis and Biological Evaluation of Diaryl‐Substituted Carboranes as Inhibitors of Hypoxia Inducible Factor (HIF)‐1 Transcriptional Activity (ChemMedChem 2/2013)
Author(s) -
Minegishi Hidemitsu,
Matsukawa Takuya,
Nakamura Hiroyuki
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201390001
Subject(s) - chemistry , proteasome , hypoxia (environmental) , angiogenesis , transcription factor , hypoxia inducible factor 1 , hypoxia inducible factors , carborane , microbiology and biotechnology , cancer research , biochemistry , stereochemistry , biology , gene , oxygen , organic chemistry
The inside cover picture shows diaromatic‐substituted icosahedral carborane, a mimic of manassantin A, which induces hypoxia inducible factor (HIF)‐1α protein degradation via the proteasome pathway, leading to inhibition of hypoxia‐induced HIF‐1 transcriptional activity and suppression of angiogenesis necessary for tumor growth. For more details, see the Full Paper by Hiroyuki Nakamura et al. on p. 265 ff.