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Development of a Growth‐Hormone‐Conjugated Nanodiamond Complex for Cancer Therapy
Author(s) -
Chu HsuehLiang,
Chen HungWei,
Tseng ShinHua,
Hsu MingHua,
Ho LiPing,
Chou FuHsuan,
Li MD. PhD. HsingYuan,
Chang YuChuan,
Chen PeiHsin,
Tsai LiYun,
Chou ChingChung,
Chen Jyh Shin,
Cheng TsaiMu,
Chang ChiaChing
Publication year - 2014
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201300541
Subject(s) - nanodiamond , cancer cell , cancer research , cancer , lung cancer , cell growth , growth hormone receptor , cell , hormone , chemistry , nanotechnology , growth hormone , medicine , materials science , biochemistry , organic chemistry , diamond
It is highly desirable to develop a therapeutic, observable nanoparticle complex for specific targeting in cancer therapy. Growth hormone (GH) and its antagonists have been explored as cancer cell‐targeting molecules for both imaging and therapeutic applications. In this study, a low toxicity, biocompatible, therapeutic, and observable GH–nanoparticle complex for specifically targeting growth hormone receptor (GHR) in cancer cells was synthesized by conjugating GH with green fluorescence protein and carboxylated nanodiamond. Moreover, we have shown that this complex can be triggered by laser irradiation to create a “nanoblast” and induce cell death in the A549 non‐small‐cell lung cancer cell line via the apoptotic pathway. This laser‐mediated, cancer‐targeting platform can be widely used in cancer therapy.