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Synthesis and Structure–Activity Relationship Studies of Quinoxaline Derivatives as Aldose Reductase Inhibitors
Author(s) -
Wu Bobin,
Yang Yanchun,
Qin Xiangyu,
Zhang Shuzhen,
Jing Chaojun,
Zhu Changjin,
Ma Bing
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201300324
Subject(s) - aldose reductase , quinoxaline , aldehyde reductase , chemistry , aldose reductase inhibitor , ic50 , acetic acid , stereochemistry , enzyme , diabetes mellitus , in vitro , biochemistry , combinatorial chemistry , pharmacology , organic chemistry , biology , endocrinology
ARIs for diabetes: A series of 2‐(3‐benzyl‐2‐oxoquinoxalin‐1(2 H )‐yl)acetic acid derivatives were designed and synthesized as inhibitors of aldose reductase (AR), a novel target for the treatment of diabetes complications. Most of the derivatives proved to be potent and selective, with IC 50 values in the low nanomolar to micromolar range.