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Targeting the K‐Ras/PDE δ Protein–Protein Interaction: The Solution for Ras‐Driven Cancers or Just Another Therapeutic Mirage?
Author(s) -
Frett Brendan,
Wang Yuanxiang,
Li Hongyu
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201300311
Subject(s) - holy grail , oncogene , anti apoptotic ras signalling cascade , protein–protein interaction , cancer research , chemistry , blocking (statistics) , computational biology , medicine , cancer , signal transduction , biology , computer science , biochemistry , mapk/erk pathway , computer network , world wide web , cell cycle
The holy grail, finally? After years of unsuccessful attempts at drugging the Ras oncogene, a recent paper by Zimmerman et al. has revealed the possibility of inhibiting Ras signaling on a clinically relevant level by blocking the K‐Ras/PDE δ protein–protein interaction. The results, reported in Nature , are highlighted herein with future implications and directions to evaluate the full clinical potential of this research.