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An Efficient Combinatorial Synthesis of Allocolchicine Analogues via a Triple Cascade Reaction and their Evaluation as Inhibitors of Insulin Aggregation
Author(s) -
Bhowmik Subhendu,
Khanna Shruti,
Srivastava Kumkum,
Hasanain Mohammad,
Sarkar Jayanta,
Verma Sandeep,
Batra Sanjay
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201300302
Subject(s) - cascade , computer science , sequence (biology) , combinatorial chemistry , service (business) , chemistry , biochemistry , business , chromatography , marketing
A controlled cascade: A divergent, diastereoselective and efficient one‐pot synthesis of allocolchicinoids via a cascade Suzuki–Michael addition–Carbocyclization sequence is described. The utility of the compounds as possible inhibitors of insulin aggregation is also presented.