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Metal‐Based Compounds as Prospective Antileishmanial Agents: Inhibition of Trypanothione Reductase by Selected Gold Complexes
Author(s) -
Colotti Gianni,
Ilari Andrea,
Fiorillo Annarita,
Baiocco Paola,
Cinellu Maria Agostina,
Maiore Laura,
Scaletti Federica,
Gabbiani Chiara,
Messori Luigi
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201300276
Subject(s) - chemistry , pharmacology , combinatorial chemistry , drug , stereochemistry , in vitro , biochemistry , biology
Picking a fight with parasites! Trypanothione reductase (TR) is a validated drug target for the development of antileishmanial agents. A group of structurally diverse gold‐containing compounds was evaluated in vitro for TR inhibition. A number of compounds exhibited potent activity and deserve further pharmacological evaluation.