Metal‐Based Compounds as Prospective Antileishmanial Agents: Inhibition of Trypanothione Reductase by Selected Gold Complexes | Zendy

Colotti Gianni | Zendy; Ilari Andrea | Zendy; Fiorillo Annarita | Zendy; Baiocco Paola | Zendy; Cinellu Maria Agostina | Zendy; Maiore Laura | Zendy; Scaletti Federica | Zendy; Gabbiani Chiara | Zendy; Messori Luigi | Zendy

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Metal‐Based Compounds as Prospective Antileishmanial Agents: Inhibition of Trypanothione Reductase by Selected Gold Complexes

Author(s) -

Colotti Gianni,

Ilari Andrea,

Fiorillo Annarita,

Baiocco Paola,

Cinellu Maria Agostina,

Maiore Laura,

Scaletti Federica,

Gabbiani Chiara,

Messori Luigi

Publication year - 2013

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.201300276

Subject(s) - chemistry , pharmacology , combinatorial chemistry , drug , stereochemistry , in vitro , biochemistry , biology

Picking a fight with parasites! Trypanothione reductase (TR) is a validated drug target for the development of antileishmanial agents. A group of structurally diverse gold‐containing compounds was evaluated in vitro for TR inhibition. A number of compounds exhibited potent activity and deserve further pharmacological evaluation.

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