Identification of Chiral Alkenyl‐ and Alkynylcarbinols as Pharmacophores for Potent Cytotoxicity | Zendy

El Arfaoui Dounia | Zendy; Listunov Dymytrii | Zendy; Fabing Isabelle | Zendy; Oukessou Mohamed | Zendy; Frongia Céline | Zendy; Lobjois Valérie | Zendy; Samson Arnaud | Zendy; Ausseil Frédéric | Zendy; BenTama Abdeslem | Zendy; El Hadrami El Mestafa | Zendy; Chauvin Remi | Zendy; Génisson Yves | Zendy

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Identification of Chiral Alkenyl‐ and Alkynylcarbinols as Pharmacophores for Potent Cytotoxicity

Author(s) -

El Arfaoui Dounia,

Listunov Dymytrii,

Fabing Isabelle,

Oukessou Mohamed,

Frongia Céline,

Lobjois Valérie,

Samson Arnaud,

Ausseil Frédéric,

BenTama Abdeslem,

El Hadrami El Mestafa,

Chauvin Remi,

Génisson Yves

Publication year - 2013

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.201300230

Subject(s) - cytotoxicity , pharmacophore , enantiomer , chemistry , stereochemistry , identification (biology) , stereoisomerism , combinatorial chemistry , molecule , organic chemistry , biochemistry , in vitro , biology , botany

Illumination by acetylene: Systematic structural variations in a series of archetypal acetylenic lipids derived from the naturally occurring ( S , E )‐icos‐4‐en‐1‐yn‐3‐ol allowed the discovery of a series of 3 R ‐like 1,4‐di‐unsaturated carbinol units with a significant and systematic enantiomeric effect on cytotoxicity.

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