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Identification of Chiral Alkenyl‐ and Alkynylcarbinols as Pharmacophores for Potent Cytotoxicity
Author(s) -
El Arfaoui Dounia,
Listunov Dymytrii,
Fabing Isabelle,
Oukessou Mohamed,
Frongia Céline,
Lobjois Valérie,
Samson Arnaud,
Ausseil Frédéric,
BenTama Abdeslem,
El Hadrami El Mestafa,
Chauvin Remi,
Génisson Yves
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201300230
Subject(s) - cytotoxicity , pharmacophore , enantiomer , chemistry , stereochemistry , identification (biology) , stereoisomerism , combinatorial chemistry , molecule , organic chemistry , biochemistry , in vitro , biology , botany
Illumination by acetylene: Systematic structural variations in a series of archetypal acetylenic lipids derived from the naturally occurring ( S , E )‐icos‐4‐en‐1‐yn‐3‐ol allowed the discovery of a series of 3 R ‐like 1,4‐di‐unsaturated carbinol units with a significant and systematic enantiomeric effect on cytotoxicity.