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N‐Substituted 1,2‐Dihydroquinolines as Anticancer Agents: Electronic Control of Redox Stability, Assessment of Antiproliferative Effects, and Mechanistic Insights
Author(s) -
John Victor Napoleon,
Sakthivel Ramasamy,
Muraleedharan Kannoth Manheri,
Karunagaran Devarajan
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201300210
Subject(s) - redox , apoptosis , chemistry , cytochrome c , dna fragmentation , caspase , fragmentation (computing) , cell cycle , mitochondrion , biophysics , biochemistry , combinatorial chemistry , microbiology and biotechnology , programmed cell death , biology , inorganic chemistry , ecology
Redox chemotherapy: Antiproliferative activities of a series of N‐substituted 1,2‐dihydroquinolines capable of causing redox imbalance in cancer cells are presented. Detailed studies showed that these derivatives arrest the cell cycle in the G 2 /M phase and induce apoptosis through an intrinsic pathway characterized by loss of mitochondrial membrane potential, DNA fragmentation, cytochrome c release, and activation of caspases 9 and 3.