Antiproliferative Activity, Cell Cycle, and Apoptosis Studies of a Series of 6‐Substituted 9 H ‐Purin‐9‐yl‐pyridinium Derivatives on a Human Cervical Carcinoma Cell Line | Zendy

RubioRuiz Belén | Zendy; RamosTorrecillas Javier | Zendy; CapitánCañadas Fermín | Zendy; SánchezMartín Rosario | Zendy; Gallo Miguel Ángel | Zendy; Espinosa Antonio | Zendy; Ruiz Concepción | Zendy; ConejoGarcía Ana | Zendy; Entrena Antonio | Zendy

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Antiproliferative Activity, Cell Cycle, and Apoptosis Studies of a Series of 6‐Substituted 9 H ‐Purin‐9‐yl‐pyridinium Derivatives on a Human Cervical Carcinoma Cell Line

Author(s) -

RubioRuiz Belén,

RamosTorrecillas Javier,

CapitánCañadas Fermín,

SánchezMartín Rosario,

Gallo Miguel Ángel,

Espinosa Antonio,

Ruiz Concepción,

ConejoGarcía Ana,

Entrena Antonio

Publication year - 2013

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.201300171

Subject(s) - pyridinium , apoptosis , cervical carcinoma , cell cycle , cell culture , series (stratigraphy) , chemistry , computer science , information retrieval , cancer research , stereochemistry , computational biology , biochemistry , biology , medicinal chemistry , genetics , cancer , paleontology , cervical cancer

Better by benzylthio: A series of 6‐substituted 9 H ‐purin‐9‐yl‐pyridinium derivatives was synthesized and evaluated for their antitumor activity. Compounds included in this study elicit variations in cell‐cycle progression and an increase of apoptotic cells in a caspase‐3‐dependent process.

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