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Synthesis of an 11 C‐Labeled Antiprion GN8 Derivative and Evaluation of Its Brain Uptake by Positron Emission Tomography
Author(s) -
Kimura Tsutomu,
Sako Takeo,
HosokawaMuto Junji,
Cui Yi Long,
Wada Yasuhiro,
Kataoka Yosky,
Doi Hisashi,
Sakaguchi Suehiro,
Suzuki Masaaki,
Watanabe Yasuyoshi,
Kuwata Kazuo
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201300167
Subject(s) - positron emission tomography , derivative (finance) , positron , computer science , radiochemistry , combinatorial chemistry , nuclear medicine , chemistry , medicine , physics , nuclear physics , business , electron , finance
A radiolabeled PET! A 11 C‐labeled derivative of N , N ′‐(methylenedi‐4,1‐phenylene)bis[2‐(1‐pyrrolidinyl) acetamide] (GN8), an antiprion agent currently under development, was synthesized by palladium‐catalyzed rapid methylation of aryltributylstannane and assessed for brain penetration and organ distribution in rats by positron emission tomography (PET).