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Design, Synthesis and Biological Evaluation of Trimethine Cyanine Dyes as Fluorescent Probes for the Detection of Tau Fibrils in Alzheimer’s Disease Brain and Olfactory Epithelium
Author(s) -
Gu Jiamin,
Anumala Upendra Rao,
Heynyvon Haußen Roland,
Hölzer Jana,
GoetschyMeyer Valérie,
Mall Gerhard,
Hilger Ingrid,
Czech Christian,
Schmidt Boris
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201300090
Subject(s) - cyanine , fluorescence , neuroscience , grey matter , chemistry , alzheimer's disease , computer science , psychology , disease , pathology , medicine , magnetic resonance imaging , physics , optics , white matter , radiology
Shedding light on grey matter: Fluorescent trimethine cyanines were evaluated as imaging probes for neurofibrillary tangles in post‐mortem brain sections of Alzheimer's disease patients. These probes bind to neurofibrillary tangles with high contrast and selectivity over amyloid β plaques.