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Radiolabeled Heterobivalent Peptidic Ligands: an Approach with High Future Potential for in vivo Imaging and Therapy of Malignant Diseases
Author(s) -
Fischer Gabriel,
Schirrmacher Ralf,
Wängler Björn,
Wängler Carmen
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201300081
Subject(s) - in vivo , cancer research , chemistry , peptide , receptor , medicine , computational biology , pharmacology , biochemistry , biology , microbiology and biotechnology
Two‐pronged synergism: We review the recently developed approach of using heterobivalent peptide ligands that interact concomitantly with different receptors on tumor cells. These ligands exhibit highly favorable tumor‐targeting properties and pave the way for the development of drugs for specific, sensitive, and noninvasive tumor imaging and therapy.