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From a Multipotent Stilbene to Soluble Epoxide Hydrolase Inhibitors with Antiproliferative Properties
Author(s) -
Buscató Estel.la,
Büttner Dominik,
Brüggerhoff Astrid,
Klingler FrancaMaria,
Weber Julia,
Scholz Bastian,
Živković Aleksandra,
Marschalek Rolf,
Stark Holger,
Steinhilber Dieter,
Bode Helge B.,
Proschak Ewgenij
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201300057
Subject(s) - epoxide hydrolase 2 , natural product , chemistry , enzyme , epoxide hydrolase , epoxide , biochemistry , hydrolase , recombinant dna , stereochemistry , cell culture , combinatorial chemistry , biology , gene , catalysis , genetics , microsome
Inspired by nature: Natural product isopropylstilbene was identified as an inhibitor of soluble epoxide hydrolase exhibiting antiproliferative properties. Following the natural product inspired design approach, a library of ( E )‐styryl‐1 H ‐benzo[ d ]imidazoles was synthesized and evaluated with recombinant enzyme and on several cancer cell lines.