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Enhanced Replication of R5 HIV‐1 Isolates in vitro by a Small‐Molecule Reagent Targeting HIV‐1 Protease
Author(s) -
Wardle Nick J.,
Hudson Harry R.,
Matthews Ray W.,
Nunn Christine M.,
Vella Cherelyn,
Bligh S. W. Annie
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201300051
Subject(s) - protease , replication (statistics) , human immunodeficiency virus (hiv) , virology , in vitro , viral replication , small molecule , biology , reagent , chemistry , virus , enzyme , biochemistry , organic chemistry
Chemical enhancement: Designed to target HIV‐1 protease, a novel γ‐hydroxyphosphonate has been found to significantly enhance viral replication in a panel of clinically relevant R5 HIV‐1 isolates. This unexpected result constitutes the first instance of a small molecule capable of doing this, and it has implications for the preparation and use of R5 isolates in vaccine and drug development.