z-logo
Premium
Enhanced Replication of R5 HIV‐1 Isolates in vitro by a Small‐Molecule Reagent Targeting HIV‐1 Protease
Author(s) -
Wardle Nick J.,
Hudson Harry R.,
Matthews Ray W.,
Nunn Christine M.,
Vella Cherelyn,
Bligh S. W. Annie
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201300051
Subject(s) - protease , replication (statistics) , human immunodeficiency virus (hiv) , virology , in vitro , viral replication , small molecule , biology , reagent , chemistry , virus , enzyme , biochemistry , organic chemistry
Chemical enhancement: Designed to target HIV‐1 protease, a novel γ‐hydroxyphosphonate has been found to significantly enhance viral replication in a panel of clinically relevant R5 HIV‐1 isolates. This unexpected result constitutes the first instance of a small molecule capable of doing this, and it has implications for the preparation and use of R5 isolates in vaccine and drug development.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here