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Cover Picture: Synthesis and Evaluation of 3,4‐Dihydropyrimidin‐2(1 H )‐ones as Sodium Iodide Symporter Inhibitors (ChemMedChem 1/2013)
Author(s) -
Lacotte Pierre,
Puente Celine,
Ambroise Yves
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201290064
Subject(s) - iodide , sodium iodide symporter , chemistry , thyroid , front cover , iodine , symporter , sodium iodide , combinatorial chemistry , cover (algebra) , pharmacology , endocrinology , biochemistry , medicine , organic chemistry , transporter , gene , mechanical engineering , engineering
The front cover picture shows the structure of a new dihydropyrimidin‐2‐one inhibitor of iodide entrapment in thyroid cells. The identification of this low‐nanomolar inhibitor was achieved through an exhaustive structure–activity relationship study in which more than a hundred derivatives in this compound family were designed, synthesized and tested. This discovery opens new perspectives for the development of antithyroid drugs designed to prevent iodide overload in the thyroid gland. For more details, see the Full Paper by Yves Ambroise et al. on p. 104 ff.