Premium
Inside Cover: Inhibition of Bacterial Dihydrofolate Reductase by 6‐Alkyl‐2,4‐diaminopyrimidines (ChemMedChem 11/2012)
Author(s) -
Nammalwar Baskar,
Bourne Christina R.,
Bunce Richard A.,
Wakeham Nancy,
Bourne Philip C.,
Ramnarayan Kal,
Mylvaganam Shankari,
Berlin K. Darrell,
Barrow Esther W.,
Barrow William W.
Publication year - 2012
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201290054
Subject(s) - dihydrofolate reductase , chemistry , alkyl , ring (chemistry) , stereochemistry , cover (algebra) , biochemistry , enzyme , organic chemistry , mechanical engineering , engineering
The inside cover picture shows a 6‐alkyl‐2,4‐diaminopyrimidine inhibitor (magenta) with a propyl at the C6 position of the 2,4‐diaminopyrimidine ring (asterisk) bound to S. aureus dihydrofolate reductase (blue model with surface shown, PDB: 4FGG). Binding triggers movement of a leucine side chain (yellow sticks), resulting in the opening of an adjacent hydrated pocket (filled with red spheres) contiguous with the binding pocket. For more details, see the Full Paper by Christina R. Bourne, Richard A. Bunce et al. on p. 1974 ff.