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Inside Cover: Structure–Activity Relationships of a Novel Group of Large‐Conductance Ca 2+ ‐Activated K + (BK) Channel Modulators: The GoSlo‐SR Family (ChemMedChem 10/2012)
Author(s) -
Roy Subhrangsu,
Morayo Akande Adebola,
Large Roddy J.,
Webb Tim I.,
Camarasu Costin,
Sergeant Gerard P.,
McHale Noel G.,
Thornbury Keith D.,
Hollywood Mark A.
Publication year - 2012
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201290048
Subject(s) - bk channel , conductance , cover (algebra) , channel (broadcasting) , smooth muscle , ion channel , overactive bladder , potassium channel , hollywood , chemistry , group (periodic table) , biophysics , nanotechnology , materials science , endocrinology , medicine , biology , physics , engineering , biochemistry , receptor , telecommunications , condensed matter physics , microbiology and biotechnology , mechanical engineering , alternative medicine , pathology , organic chemistry
The inside cover picture shows two members of the GoSlo‐SR family of BK channel modulators that activate channels at physiological potentials. These were developed by the Smooth Muscle Research and Ion Channel Biotechnology Centres in Ireland and may form a scaffold for the future development of smooth‐muscle‐specific relaxants to help treat overactive bladder, hypertension or asthma. For more details, see the Communication by Mark A. Hollywood et al. on p. 1763 ff.