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Back Cover: Cinnamic Acid/Chloroquinoline Conjugates as Potent Agents against Chloroquine‐Resistant Plasmodium falciparum (ChemMedChem 9/2012)
Author(s) -
Pérez Bianca,
Teixeira Cátia,
Gut Jiri,
Rosenthal Philip J.,
Gomes José R. B.,
Gomes Paula
Publication year - 2012
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201290046
Subject(s) - plasmodium falciparum , chloroquine , cinnamic acid , chemistry , conjugate , pharmacology , combinatorial chemistry , stereochemistry , traditional medicine , malaria , biology , biochemistry , medicine , immunology , mathematical analysis , mathematics
The back cover picture shows a novel warhead against intraerythrocytic malaria parasites. Chloroquinoline–cinnamic acid conjugates display activities in the low nanomolar range against chloroquine‐resistant Plasmodium falciparum. In the image, the general structure of such conjugates is depicted targeting a blood schizont of the 3D7 Pf strain (image from Gut and Rosenthal). For more details, see the Communication by Paula Gomes et al. on p. 1537 ff.