Premium
Inside Cover: Effects of Cyclic Lipodepsipeptide Structural Modulation on Stability, Antibacterial Activity, and Human Cell Toxicity (ChemMedChem 5/2012)
Author(s) -
Bionda Nina,
Stawikowski Maciej,
Stawikowska Roma,
Cudic Maré,
LópezVallejo Fabian,
Treitl Daniela,
MedinaFranco José,
Cudic Predrag
Publication year - 2012
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201290019
Subject(s) - amide , selectivity , chemistry , peptide bond , cover (algebra) , antibacterial activity , combinatorial chemistry , stereochemistry , biophysics , bacteria , organic chemistry , peptide , biochemistry , biology , mechanical engineering , engineering , genetics , catalysis
The inside cover picture shows that replacement of the ester bond in cyclic lipodepsipeptide antibiotics with an amide bond affords equipotent analogues with improved serum stability. The amide derivatives show improved selectivity for bacterial over host cells, probably due to their lower overall hydrophobicity and amphiphilicity. For more details, see the Full Paper by Predrag Cudic et al. on p. 871 ff.