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Inside Cover: Investigation of D 2 Receptor–Agonist Interactions Using a Combination of Pharmacophore and Receptor Homology Modeling / Investigation of D 1 Receptor–Agonist Interactions and D 1 /D 2 Agonist Selectivity Using a Combination of Pharmacophore and Receptor Homology Modeling (ChemMedChem 3/2012)
Author(s) -
Malo Marcus,
Brive Lars,
Luthman Kristina,
Svensson Peder
Publication year - 2012
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201290007
Subject(s) - pharmacophore , agonist , receptor , homology modeling , endogenous agonist , chemistry , dopamine , homology (biology) , stereochemistry , dopamine receptor d1 , biochemistry , biology , neuroscience , amino acid , enzyme
The inside cover picture shows the endogenous neurotransmitter dopamine, the D 1 (doxanthrine) and D 2 ( R ‐NPA) agonists, and models of their targets (D 1 in blue and D 2 in yellow). Pharmacophore and homology modeling was used to predict the interactions of these ligands with the dopamine receptors. For more details, see the back‐to‐back Full Papers by Peder Svensson et al. on p. 471 and 483 ff.