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[ 3 H]UR‐PLN196: A Selective Nonpeptide Radioligand and Insurmountable Antagonist for the Neuropeptide Y Y 2 Receptor
Author(s) -
Pluym Nikola,
Baumeister Paul,
Keller Max,
Bernhardt Günther,
Buschauer Armin
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201200566
Subject(s) - radioligand , neuropeptide y receptor , antagonist , neuropeptide , chemistry , guanidine , receptor , receptor antagonist , stereochemistry , radioligand assay , endocrinology , pharmacology , medicine , biology , biochemistry
Radioing in on NPY: Attachment of a [2,3‐ 3 H]propionyl group through an appropriate linker to the guanidine group of an ( S )‐argininamide‐type neuropeptide Y (NPY) Y 2 receptor antagonist resulted in a subtype‐selective radioligand.
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