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Synthesis, Characterization and Pharmacodynamics of Vitamin‐B 12 ‐Conjugated Glucagon‐Like Peptide‐1
Author(s) -
ClardyJames Susan,
Chepurny Oleg G.,
Leech Colin A.,
Holz George G.,
Doyle Robert P.
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201200461
Subject(s) - conjugate , glucagon like peptide 1 , peptide , chemistry , vitamin b , pharmacodynamics , pharmacology , conjugated system , biochemistry , diabetes mellitus , vitamin , endocrinology , medicine , pharmacokinetics , type 2 diabetes , mathematical analysis , mathematics , organic chemistry , polymer
Clearing the way: Glucagon‐like peptide‐1 (GLP‐1) receptor agonists are proving a potent weapon in the treatment of type II diabetes. A new vitamin B 12 –GLP‐1 conjugate is investigated and shown to have insulinotropic properties similar to the unmodified peptide. These results are critical to the exploitation of the vitamin B 12 oral uptake pathway for peptide delivery.