Synthesis, Characterization and Pharmacodynamics of Vitamin‐B 12 ‐Conjugated Glucagon‐Like Peptide‐1 | Zendy

ClardyJames Susan | Zendy; Chepurny Oleg G. | Zendy; Leech Colin A. | Zendy; Holz George G. | Zendy; Doyle Robert P. | Zendy

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Synthesis, Characterization and Pharmacodynamics of Vitamin‐B 12 ‐Conjugated Glucagon‐Like Peptide‐1

Author(s) -

ClardyJames Susan,

Chepurny Oleg G.,

Leech Colin A.,

Holz George G.,

Doyle Robert P.

Publication year - 2013

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.201200461

Subject(s) - conjugate , glucagon like peptide 1 , peptide , chemistry , vitamin b , pharmacodynamics , pharmacology , conjugated system , biochemistry , diabetes mellitus , vitamin , endocrinology , medicine , pharmacokinetics , type 2 diabetes , mathematical analysis , mathematics , organic chemistry , polymer

Clearing the way: Glucagon‐like peptide‐1 (GLP‐1) receptor agonists are proving a potent weapon in the treatment of type II diabetes. A new vitamin B 12 –GLP‐1 conjugate is investigated and shown to have insulinotropic properties similar to the unmodified peptide. These results are critical to the exploitation of the vitamin B 12 oral uptake pathway for peptide delivery.

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