Premium
A Facile Synthesis of Novel Bis‐(indolyl)‐1,3,4‐oxadiazoles as Potent Cytotoxic Agents
Author(s) -
Kumar Dalip,
Arun V.,
Maruthi Kumar N.,
Acosta Glen,
Noel Brett,
Shah Kavita
Publication year - 2012
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201200363
Subject(s) - cytotoxicity , chemistry , hydrazide , combinatorial chemistry , iodobenzene , cytotoxic t cell , stereochemistry , organic chemistry , biochemistry , in vitro , catalysis
A recipe for potency: A novel series of bis(indolyl)‐1,3,4‐oxadiazoles was prepared from the corresponding hydrazide‐hydrazones via iodobenzene diacetate‐promoted oxidative cyclization. Evaluation against a panel of human cancer cell lines revealed that some derivatives possess potent cytotoxicity with tunable selectivity for different cancer types.