Synthesis and Structure–Activity Relationships of Lansine Analogues as Antileishmanial Agents | Zendy

Pieroni Marco | Zendy; Girmay Sisay | Zendy; Sun Dianqing | Zendy; Sahu Rajnish | Zendy; Tekwani Babu L. | Zendy; Tan Ghee T. | Zendy

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Synthesis and Structure–Activity Relationships of Lansine Analogues as Antileishmanial Agents

Author(s) -

Pieroni Marco,

Girmay Sisay,

Sun Dianqing,

Sahu Rajnish,

Tekwani Babu L.,

Tan Ghee T.

Publication year - 2012

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.201200346

Subject(s) - pharmacy , medicine , library science , family medicine , computer science

Clear and rational thinking: A series of rationally designed, lansine‐derived carbazoles was synthesized and evaluated for activity against promastigotes and amastigotes of Leishmania donovani , the causative agent of leishmaniasis. Some structural modifications gave rise to compounds with enhanced activity and selectivity over lansine, allowing structure–activity relationships to be elucidated and providing a foundation for the further development of this pharmacophore.

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