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Synthesis and Antiproliferative Activity of the Ring System [1,2]Oxazolo[4,5‐ g ]indole
Author(s) -
Barraja Paola,
Caracausi Libero,
Diana Patrizia,
Spanò Virginia,
Montalbano Alessandra,
Carbone Anna,
Parrino Barbara,
Cirrincione Girolamo
Publication year - 2012
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201200296
Subject(s) - indole test , ring (chemistry) , stereochemistry , chemistry , order (exchange) , computer science , library science , information retrieval , organic chemistry , business , finance
Brand new ring: A series of 27 derivatives of the new ring system [1,2]oxazolo[4,5‐ g ]indole were conveniently prepared and tested at the NCI for antiproliferative studies. Several of them showed good inhibitory activity toward all tested cell lines, reaching GI 50 values generally at the micromolar and sub‐ micromolar levels and in some cases at nanomolar concentrations. The mean GI 50 values, calculated on the full panel, were in the range 0.25–7.08 μ M .