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Identification of a 17β‐Hydroxysteroid Dehydrogenase Type 10 Steroidal Inhibitor: A Tool to Investigate the Role of Type 10 in Alzheimer’s Disease and Prostate Cancer
Author(s) -
Ayan Diana,
Maltais René,
Poirier Donald
Publication year - 2012
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201200129
Subject(s) - androsterone , prostate cancer , hydroxysteroid dehydrogenase , disease , dehydrogenase , hydroxysteroid dehydrogenases , identification (biology) , cancer , computational biology , cancer research , nad+ kinase , enzyme , biochemistry , bioinformatics , chemistry , medicine , biology , hormone , steroid , botany
Ten out of ten! Androsterone derivatives inhibit 17β‐hydroxysteroid dehydrogenase type 10 (17β‐HSD10), a versatile mitochondrial NAD + ‐dependent enzyme with potential roles in both Alzheimer's disease and prostate cancer. These androsterone derivatives could be useful tool compounds to help elucidate the role of 17β‐HSD10 in these important diseases.