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Structural Determination of NSC 670224, Synthesis of Analogues and Biological Evaluation
Author(s) -
Zuckerman Nathaniel B.,
Myers Andrew S.,
Quan Tiffani K.,
Bray Walter M.,
Lokey R. Scott,
Hartzog Grant A.,
Konopelski Joseph P.
Publication year - 2012
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201200038
Subject(s) - computational biology , chemistry , stereochemistry , combinatorial chemistry , biology
Follow my lead! NSC 670224, previously shown to be toxic to Saccharomyces cerevisiae at low micromolar concentrations, potentially acts via a mechanism of action related to that of tamoxifen (NSC 180973), breast cancer drug. The structure of NSC 670224, previously thought to be a 2,4‐dichloro arene, was established as the 3,4‐dichloro arene, and a focused library of analogues were synthesized and biologically evaluated.