Structural Determination of NSC 670224, Synthesis of Analogues and Biological Evaluation | Zendy

Zuckerman Nathaniel B. | Zendy; Myers Andrew S. | Zendy; Quan Tiffani K. | Zendy; Bray Walter M. | Zendy; Lokey R. Scott | Zendy; Hartzog Grant A. | Zendy; Konopelski Joseph P. | Zendy

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Structural Determination of NSC 670224, Synthesis of Analogues and Biological Evaluation

Author(s) -

Zuckerman Nathaniel B.,

Myers Andrew S.,

Quan Tiffani K.,

Bray Walter M.,

Lokey R. Scott,

Hartzog Grant A.,

Konopelski Joseph P.

Publication year - 2012

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.201200038

Subject(s) - computational biology , chemistry , stereochemistry , combinatorial chemistry , biology

Follow my lead! NSC 670224, previously shown to be toxic to Saccharomyces cerevisiae at low micromolar concentrations, potentially acts via a mechanism of action related to that of tamoxifen (NSC 180973), breast cancer drug. The structure of NSC 670224, previously thought to be a 2,4‐dichloro arene, was established as the 3,4‐dichloro arene, and a focused library of analogues were synthesized and biologically evaluated.

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