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Back Cover: Identification and Characterization of Inhibitors of the Aminoglycoside Resistance Acetyltransferase Eis from Mycobacterium tuberculosis (ChemMedChem 1/2012)
Author(s) -
Green Keith D.,
Chen Wenjing,
GarneauTsodikova Sylvie
Publication year - 2012
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201190063
Subject(s) - aminoglycoside , mycobacterium tuberculosis , tuberculosis , antibiotics , microbiology and biotechnology , chemistry , medicine , combinatorial chemistry , pharmacology , biology , pathology
The back cover picture shows Eis, the enzyme that converts aminoglycoside antibiotics from their active (green) to their inactive (red) form, a process that causes drug resistance in tuberculosis (TB). The compounds shown are the first examples of Eis inhibitors, which could find application in combination therapies with aminoglycosides to treat TB. For more details, please see the Communication by Sylvie Garneau‐Tsodikova et al. on p. 73 ff.