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Inside Cover: A Heterodimeric Glucuronide Prodrug for Cancer Tritherapy: the Double Role of the Chemical Amplifier (ChemMedChem 12/2011)
Author(s) -
Grinda Marion,
Clarhaut Jonathan,
TranoyOpalinski Isabelle,
Renoux Brigitte,
Monvoisin Arnaud,
Cronier Laurent,
Papot Sébastien
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201190053
Subject(s) - prodrug , cover (algebra) , chemistry , combinatorial chemistry , drug delivery , glucuronide , nanotechnology , materials science , engineering , biochemistry , organic chemistry , metabolism , mechanical engineering
The inside cover picture shows a nontoxic targeting system programmed for the selective delivery of three different cytotoxic agents to the tumor site. This system includes a chemical amplifier that transforms a single tumor‐associated enzymatic triggering event into the release of a highly toxic drug cocktail. For more details, see the Communication by Sébastien Papot et al. on p. 2137 ff.