Premium
Inside Cover: Inhibition of Aminoglycoside‐Deactivating Enzymes APH(3′)‐IIIa and AAC(6′)‐Ii by Amphiphilic Paromomycin O2′′‐Ether Analogues (ChemMedChem 11/2011)
Author(s) -
Szychowski Janek,
Kondo Jiro,
Zahr Omar,
Auclair Karine,
Westhof Eric,
Hanessian Stephen,
Keillor Jeffrey W.
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201190048
Subject(s) - amphiphile , aminoglycoside , paromomycin , chemistry , cover (algebra) , ether , stereochemistry , imidazole , combinatorial chemistry , biochemistry , antibiotics , organic chemistry , mechanical engineering , polymer , engineering , copolymer
The inside cover picture shows a semi‐synthetic amphiphilic aminoglycoside, active against S. aureus and E. coli , binding in the bacterial ribosomal decoding A site. Aminoglycoside ring I makes a pseudo pair with universally conserved A1408. The hydrophobic ether chain extends across the deep groove and points into the solvent. For more details, see the Communication by Stephen Hanessian, Jeffrey W. Keillor et al. on p. 1961 ff.