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Inside Cover: Two Distinct Conformations of GABA Locked by Embedding in the Bicyclo[3.1.0]hexane Core Structure (ChemMedChem 10/2011)
Author(s) -
Jimeno Ciril,
Pericàs Miquel A.,
Wessel Hans Peter,
Alker André,
Müller Klaus
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201190043
Subject(s) - bicyclic molecule , hexane , core (optical fiber) , embedding , chemistry , stereochemistry , cover (algebra) , computer science , physics , organic chemistry , optics , engineering , artificial intelligence , mechanical engineering
The inside cover picture shows a Cambridge Structural Database (CSD) boy bubbling a scatter plot across the sky representing the preference of the bicyclo[3.1.0]hexane system to adopt a boat over a chair‐type conformation, largely independently of substitution patterns. This can be used to constrain the conformtion of acyclic units—as was prototypically explored for two bicyclic GABA derivatives—by embedding them into this bicyclic core structure, provided that the latter is conformationally sufficiently robust. For more details, see the Communication by Klaus Müller et al. on p. 1792 ff.