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Cover Picture: ( S )‐ and ( R )‐Fluoxetine as Native Markers in Mass Spectrometry (MS) Binding Assays Addressing the Serotonin Transporter (ChemMedChem 10/2011)
Author(s) -
Hess Marielle,
Höfner Georg,
Wanner Klaus T.
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201190042
Subject(s) - serotonin transporter , mass spectrometry , chemistry , transporter , cover (algebra) , triple quadrupole mass spectrometer , fluoxetine , serotonin , ligand (biochemistry) , computational biology , chromatography , biochemistry , tandem mass spectrometry , biology , selected reaction monitoring , receptor , gene , engineering , mechanical engineering
The cover picture shows a label‐free screening technique to characterize target–ligand interactions. In the foreground, a triple quadrupole mass spectrometer positioned in a flowering meadow illustrates the environmentally friendly opportunity to realize binding assays based on mass spectrometric quantification of a nonlabeled marker compound for a desired target. By peeling back the illustration of this concept—referred to as MS binding assays—the cover picture visualizes the implementation of this approach to the serotonin transporter (SERT). The study describes the efforts to address binding of nonlabeled fluoxetine enantiomers to SERT, as well as the promising results generated by the application of this MS binding assay strategy. For more details, see the Full Paper by Klaus T. Wanner et al. on p. 1900 ff.