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Cover Picture: Identification of Benzopyran‐4‐one Derivatives (Isoflavones) as Positive Modulators of GABA A Receptors (ChemMedChem 8/2011)
Author(s) -
Gavande Navnath,
Karim Nasiara,
Johnston Graham A. R.,
Hanrahan Jane R.,
Chebib Mary
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201190032
Subject(s) - isoflavones , gabaa receptor , ion channel , chloride channel , chloride , receptor , chemistry , cover (algebra) , protein subunit , biophysics , pharmacology , stereochemistry , neuroscience , biochemistry , biology , organic chemistry , mechanical engineering , engineering , gene
The cover picture shows five subunits assembled from seven subunit subfamilies ( α 1–6 , β 1–3 , γ 1–3 , δ , ε, θ and π ) to form a heteropentameric chloride‐permeable channel. Binding of γ ‐aminobutyric acid (GABA) and isoflavones triggers the opening of the channel, causing the rapid influx of chloride ions into the cell. Enhancement of chloride ion influx at GABA A receptors by positive modulators is one of the most powerful therapeutic strategies for the treatment of central nervous system (CNS)‐related disorders. For more details, see the Communication by Mary Chebib et al. on p. 1340 ff.