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Cover Picture: Biphenyl Sulfonylamino Methyl Bisphosphonic Acids as Inhibitors of Matrix Metalloproteinases and Bone Resorption (ChemMedChem 7/2011)
Author(s) -
Rubino Maria Teresa,
Agamen Mariangela,
Campestre Cristina,
Campiglia Pietro,
Cremasco Viviana,
Faccio Roberta,
Laghezza Antonio,
Loiodice Fulvio,
Maggi Dariana,
Panza Emilia,
Rossello Armando,
Tortorella Paolo
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201190027
Subject(s) - osteoclast , matrix metalloproteinase , chemistry , bone resorption , diphosphonates , biphenyl , medicine , endocrinology , biochemistry , receptor , organic chemistry
The cover picture shows a biphenyl sulfonylamino methyl bisphosphonic acid docked into the matrix metalloproteinases (MMP)‐2 active site and an osteoporotic bone where enhanced osteoclast activation leads to bone disruption. Osteoclasts stained with DAPI (blue), tubulin (green) and actin (red) are shown in the background. Biphenyl sulfonylamino methyl bisphosphonic acids possess considerable antiresorptive efficacy and exhibit MMP‐2/MMP‐8 inhibition activity; hence, they can be considered potential anticancer agents for the treatment of tumor‐induced bone disease characterized by increased osteoclast activity. For more information, see the Full Paper by Paolo Tortorella, et al. on p. 1258 ff.