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Cover Picture: BZM055, an Iodinated Radiotracer Candidate for PET and SPECT Imaging of Myelin and FTY720 Brain Distribution (ChemMedChem 4/2011)
Author(s) -
Briard Emmanuelle,
Orain David,
Beerli Christian,
Billich Andreas,
Streiff Markus,
Bigaud Marc,
Auberson Yves P.
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201190010
Subject(s) - positron emission tomography , pet imaging , tracer , single photon emission computed tomography , nuclear medicine , myelin , neuroimaging , chemistry , preclinical imaging , spect imaging , emission computed tomography , in vivo , neuroscience , medicine , physics , central nervous system , psychology , biology , nuclear physics , microbiology and biotechnology
The cover picture shows BZM055, a novel tracer for positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging based on the structure of FTY720 (Gylenia). BZM055 was developed to mimic FTY720, and study the pharmacokinetic properties and organ distribution of the drug in multiple sclerosis patients. In vivo detection of BZM055 relies on its radioactive decay, resulting in the production of gamma photons. These can be detected by a scanning device, allowing the construction of an image that reflects the distribution of the drug in the brain. Since FTY720 accumulates in the myelin sheath, BZM055 might also be used as a tracer for myelin. For more details, see the Full Paper by Emmanuelle Briard et al. on p. 667 ff.