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Cover Picture: Synthesis and Evaluation of Indatraline‐Based Inhibitors for Trypanothione Reductase / Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1 / Modified 5′‐Trityl Nucleosides as Inhibitors of Plasmodium falciparum dUTPase (ChemMedChem 2/2011)
Author(s) -
Walton Jeffrey G. A.,
Jones Deuan C.,
Kiuru Paula,
Durie Alastair J.,
Westwood Nicholas J.,
Fairlamb Alan H.,
Spinks Daniel,
Ong Han B.,
Mpamhanga Chidochangu P.,
Shanks Emma J.,
Robinson David A.,
Collie Iain T.,
Read Kevin D.,
Frearson Julie A.,
Wyatt Paul G.,
Brenk Ruth,
Fairlamb Alan H.,
Gilbert Ian H.,
Ruda Gian Filippo,
Nguyen Corinne,
Ziemkowski Przemysław,
Felczak Krzysztof,
Kasinathan Ganasan,
MussoBuendia Alexander,
Sund Christian,
Zhou Xiao Xiong,
Kaiser Marcel,
RuizPérez Luis M.,
Brun Reto,
Kulikowski Tadeusz,
Johansson Nils Gunnar,
GonzálezPacanowska Dolores,
Gilbert Ian H.
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201190000
Subject(s) - trypanosoma brucei , malaria , pteridine , african trypanosomiasis , eflornithine , biology , reductase , neglected tropical diseases , biochemistry , pharmacology , enzyme , trypanosomiasis , virology , immunology , medicine , disease , gene , spermidine , pathology
Better and safer drugs are required for neglected tropical diseases, such as malaria and the trypanosomatid diseases, human African trypanosomiasis, Chagas disease and leishmaniasis. However, these are “diseases of poverty” and therefore not economically viable for pharmaceutical companies to invest in at the early stage of drug discovery. For this reason, research conducted in an academic and nonprofit setting is of particular importance in filling this critical gap. The cover picture shows inhibitors of a drug target in malaria (dUTPase, upper right) and two enzyme targets common to the trypanosomatid diseases (trypanothione reductase, lower left; pteridine reductase 1, lower right). The cover also shows a transmission electron micrograph (upper left) of a late trophozoite stage of a malaria parasite (cyan) infecting an erythrocyte (magenta), and a scanning electron micrograph of a bloodstream form of the African trypanosome (bottom centre). For more details, see the Full Papers by Nicholas J. Westwood, Alan H. Fairlamb et al. ( p. 321 ff ), and Ian H. Gilbert et al. ( p. 302 ff and p. 309 ff ).