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In Silico Identification of an Interferon Inhibitor
Author(s) -
Kaiser Markus,
Ottmann Christian
Publication year - 2012
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100579
Subject(s) - in silico , identification (biology) , computational biology , interferon , chemistry , biology , virology , biochemistry , gene , botany
Inhibition of IFNα–IFNR: Interferon (IFN) is an important signaling molecule and antiviral therapeutic agent. However, in certain diseases like type I diabetes, IFN action can be harmful. Schneider and co‐workers recently reported the identification of the first IFNα–IFNR inhibitor via in silico screening, which binds to IFNα and impedes interferon signaling in cells.