Synthesis of Simplified Tedanolide Analogues—Connecting Tedanolide to Myriaporone and Gephyronic Acid | Zendy

Diaz Nina | Zendy; Naini Arun | Zendy; Muthukumar Yazh | Zendy; Sasse Florenz | Zendy; Kalesse Markus | Zendy

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Synthesis of Simplified Tedanolide Analogues—Connecting Tedanolide to Myriaporone and Gephyronic Acid

Author(s) -

Diaz Nina,

Naini Arun,

Muthukumar Yazh,

Sasse Florenz,

Kalesse Markus

Publication year - 2012

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.201100576

Subject(s) - potency , natural product , in vitro , chemistry , cell culture , stereochemistry , cancer cell lines , combinatorial chemistry , structure–activity relationship , computational biology , biochemistry , pharmacology , cancer cell , cancer , biology , genetics

Southern belles! Simplified analogues of tedanolide, a natural product with picomolar activity against a range of tumor cell lines, were synthesized and evaluated for potency in mammalian cancer cells. The truncated analogues were found to retain significant activity in vitro (23 μmol mL −1 for the example shown) compared with the parent compound tedanolide (0.33 nmol mL −1 ), and represent potential leads for the development of novel anticancer agents.

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