Premium
Synthesis and Evaluation of Anticancer Natural Product Analogues Based on Angelmarin: Targeting the Tolerance towards Nutrient Deprivation
Author(s) -
Magolan Jakob,
Adams Nathan B. P.,
Onozuka Hiroko,
Hungerford Natasha L.,
Esumi Hiroyasu,
Coster Mark J.
Publication year - 2012
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100564
Subject(s) - natural product , cytotoxicity , chemistry , mode of action , structure–activity relationship , biochemistry , pharmacology , combinatorial chemistry , computational biology , biology , in vitro
Inspired by nature: Angelmarin is an anticancer natural product with potent antiausterity activity, that is, selective cytotoxicity towards nutrient‐deprived, resistant cancer cells. Through structure–activity relationship studies, three analogues were identified as lead compounds for the develpoment of molecular probes for the investigation of the mode of action and biological targets of the antiausterity compounds.