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Discovery of Novel Stem Cell Mobilizers That Target the CXCR4 Receptor
Author(s) -
Wu ChienHuang,
Chang ChunPing,
Song JenShin,
Jan JiingJyh,
Chou MingChen,
Wu SzuHuei,
Yeh KaiChia,
Wong YingChieh,
Hsieh ChiehJui,
Chen ChiungTong,
Kao TzuTing,
Wu SuYing,
Yeh ChingFang,
Tseng ChenTso,
Chao YuSheng,
Shia KakShan
Publication year - 2012
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100525
Subject(s) - cxcr4 , stem cell , regenerative medicine , receptor , polyamine , drug discovery , chemistry , computational biology , microbiology and biotechnology , biology , biochemistry , chemokine
Going mobile: Based on screening hit 1 , a novel class of polyamine compounds, as represented by compound 8 , were identified as potent and selective CXCR4 antagonists. CXCR4‐targeted molecules, as demonstrated by the marketed AMD3100 and 8 , are able to mobilize stem cells from bone marrow effectively and are expected to have broad utility in cell therapy and regenerative medicine.