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In vivo Enhancement in Bioavailability of Atazanavir in the Presence of Proton‐Pump Inhibitors using Mesoporous Materials
Author(s) -
Xia Xin,
Zhou Chunfang,
Ballell Lluís,
GarciaBennett Alfonso E.
Publication year - 2012
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100500
Subject(s) - atazanavir , bioavailability , drug , human immunodeficiency virus (hiv) , pharmacology , in vivo , chemistry , computer science , nanotechnology , antiretroviral therapy , medicine , materials science , viral load , virology , biology , microbiology and biotechnology
Matters of the HAART! The current treatment for human immunodeficiency virus (HIV), HAART, makes use of a combination of antiretroviral drugs, which are poorly soluble in aqueous media. Enhancing the solubility of such drugs through the use of mesoporous materials could lead to improved treatment efficiency and might provide a solution to the drug–drug interaction problems associated with these types of therapeutic regimes.