Remarkable Stability and Cytostatic Effect of a Quercetin Conjugate, 3,7‐Bis‐ O ‐Pivaloxymethyl (POM) Quercetin | Zendy

Kim Mi Kyoung | Zendy; Park KwangSu | Zendy; Chong Youhoon | Zendy

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Remarkable Stability and Cytostatic Effect of a Quercetin Conjugate, 3,7‐Bis‐ O ‐Pivaloxymethyl (POM) Quercetin

Author(s) -

Kim Mi Kyoung,

Park KwangSu,

Chong Youhoon

Publication year - 2012

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.201100478

Subject(s) - conjugate , quercetin , cytoplasm , derivative (finance) , chemistry , hydrolysis , tumor cells , combinatorial chemistry , stereochemistry , biochemistry , mathematics , cancer research , biology , antioxidant , mathematical analysis , financial economics , economics

Stable conjugates: Two pivaloxymethyl (POM) groups were introduced at the 3‐ and 7‐hydroxy groups of quercetin to provide a 3,7‐bis‐ O ‐POM derivative (shown) with exceptional stability in cell culture media and efficient cellular uptake. Hydrolyzed to the 3‐ O ‐POM derivative in cytoplasm, the quercetin conjugate exhibits a significant cytostatic effect in various cancer cell lines.

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