Premium
Remarkable Stability and Cytostatic Effect of a Quercetin Conjugate, 3,7‐Bis‐ O ‐Pivaloxymethyl (POM) Quercetin
Author(s) -
Kim Mi Kyoung,
Park KwangSu,
Chong Youhoon
Publication year - 2012
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100478
Subject(s) - conjugate , quercetin , cytoplasm , derivative (finance) , chemistry , hydrolysis , tumor cells , combinatorial chemistry , stereochemistry , biochemistry , mathematics , cancer research , biology , antioxidant , mathematical analysis , financial economics , economics
Stable conjugates: Two pivaloxymethyl (POM) groups were introduced at the 3‐ and 7‐hydroxy groups of quercetin to provide a 3,7‐bis‐ O ‐POM derivative (shown) with exceptional stability in cell culture media and efficient cellular uptake. Hydrolyzed to the 3‐ O ‐POM derivative in cytoplasm, the quercetin conjugate exhibits a significant cytostatic effect in various cancer cell lines.