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Curaxins: A New Family of Non‐genotoxic Multitargeted Anticancer Agents
Author(s) -
Di Bussolo Valeria,
Minutolo Filippo
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100476
Subject(s) - dna damage , chemistry , tumor promotion , toxicity , programmed cell death , cancer research , dna , pharmacology , computational biology , biology , apoptosis , carcinogenesis , biochemistry , gene , organic chemistry
As a matter of FACT! Carbazoles known as curaxins effectively bind the heterodimeric protein complex, FACT, the sequestration of which causes promotion of multiple pathways (p53 activation and NF‐ κ B inhibition) leading to tumor cell death, without inducing DNA damage. Given these results, curaxins hold promise for the development of effective anticancer therapies with decreased toxicity.