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Study of the Anticancer Properties of Tin(IV) Carboxylate Complexes on a Panel of Human Tumor Cell Lines
Author(s) -
RocamoraReverte Lourdes,
CarrascoGarcía Estefanía,
CeballosTorres Jesús,
Prashar Sanjiv,
Kaluđerović Goran N.,
Ferragut José A.,
GómezRuiz Santiago
Publication year - 2012
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100432
Subject(s) - cytotoxic t cell , p glycoprotein , cell culture , apoptosis , chemistry , cytotoxicity , efflux , viability assay , k562 cells , stereochemistry , cell , biochemistry , multiple drug resistance , microbiology and biotechnology , biology , in vitro , genetics , antibiotics
A group of organotin(IV) complexes were prepared: [SnCy 3 (DMNI)] ( 1 ), [SnCy 3 (BZDO)] ( 2 ), [SnCy 3 (DMFU)] ( 3 ), and [SnPh 2 (BZDO) 2 ] ( 4 ), for which DMNIH=2,6‐dimethoxynicotinic acid, BZDOH=1,4‐benzodioxane‐6‐carboxylic acid, and DMFUH=2,5‐dimethyl‐3‐furoic acid. The cytotoxic activities of compounds 1 – 4 were tested against pancreatic carcinoma (PANC‐1), erythroleukemia (K562), and two glioblastoma multiform (U87 and LN‐229) human cell lines; they show very high antiproliferative activity, with IC 50 values in the 150–700 n M range after incubation for 72 h. Distribution of cellular DNA upon treatment with 1 – 4 revealed that whereas compounds 1 – 3 induce apoptosis in most of the cell lines, compound 4 does not affect cell viability in any cell line tested, indicating a possible difference in cytotoxic mechanism. Studies with the daunomycin‐resistant K562/R cell line expressing P‐glycoprotein (Pgp) showed that compounds 1 – 4 are not substrates of this protein efflux pump, indicating that these compounds do not induce acquisition of multidrug resistance, which is associated with the overexpression of Pgp.