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Runaway ROS as a Selective Anticancer Strategy
Author(s) -
Parkinson Elizabeth I.,
Hergenrother Paul J.
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100381
Subject(s) - reactive oxygen species , oxidative stress , chemistry , computational biology , small molecule , cancer research , pharmacology , combinatorial chemistry , biology , biochemistry
From Nature ′s medicine cabinet! Small‐molecule screening followed by sophisticated target identification were used by Raj et al. to identify the potential anticancer agent, piperlongumine. Its selectivity for cancer in tissue culture and murine models is likely due to its effects on the oxidative stress pathway. The findings reported by Raj et al., highlighted here, support the concept of targeting reactive oxygen species (ROS) as a selective anticancer strategy.